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Is confounded by study quality. Stroke 2008; 39: 2824?829. 14 Sena ES, Briscoe CL, Howells DW, Donnan GA, Sandercock PA, Macleod MR. Factors affecting the apparent efficacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysis. J Cereb Blood Flow Metab 2010; 30: 1905?913. 15 Henderson VC, Kimmelman J, Fergusson D, Grimshaw JM, Hack

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