Nire gunea - Stimulation might involve activation of PI3K/Akt, since different studies http://tracker.guca.es/News/stimulation-might-involve-activation-of-pi3kakt-since-different-studies/ Stimulation might involve activation of PI3K/Akt, since different studies imply that hyperactivation of the PI3K/Akt pathway renders Tcons resistant to Treg-mediated suppression (Wohlfert and Clark, 2007). For example, T cell-specific TRAF6 deletion led to hyperactivation of the PI3K/Akt pathway, resistance to Treg-mediated suppression and T cell-mediated autoimmune disease (King et al., 2006). Ho Thu, 07 Dec 2017 16:50:27 PST en